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Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading.
However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model. Please enable it to take advantage of the complete set of features!
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Save Cancel. Create a file for external citation management software Create file Cancel. of items displayed: 5 10 15 20 50 Create RSS Boobies nudes. RSS Link Copy. Boobies nudes Display options Display options. Abstract Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. Similar articles lacZ transduced human breast cancer xenografts as an in vivo model for the study of invasion and metastasis. Eur J Cancer. PMID: Human breast carcinoma xenografts in nude mice.
Li Z, et al. Chin Med J Engl. Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. Kurebayashi J, et al. Cancer Res. Dietary fat and breast cancer metastasis by human tumor xenografts. Rose DP, et al. Breast Cancer Res Treat. PMID: Review.
Studies of human breast cancer metastasis using nude mice. Price JE, et al. Cancer Metastasis Rev. See all similar articles. Lu N, et al. Oncol Rep. Epub Dec 2. Lysophosphatidic acid enhances breast cancer cells-mediated osteoclastogenesis. Nam JS, et al. Korean J Physiol Pharmacol. Epub Aug Human cancer evolution in the context of a human immune system in mice. Gammelgaard OL, et al. Mol Oncol. Epub Sep 3. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction.
So EY, Ouchi T. So EY, et al. BMC Cancer. Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains. Economopoulos V, et al. PLoS One. Epub Nov 9. See all "Cited by" articles. References Int J Cancer. Publication types Research Support, Non-U. Gov't Actions. MeSH terms Animals Actions. Female Actions. Genetic Markers Actions.
Humans Actions. Mice Actions. Neoplasm Invasiveness Actions. Neoplasm Metastasis Actions. Neoplasm Transplantation Actions. Species Specificity Actions. Transplantation, Heterologous Actions.
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